The main character in the survival horror third-person shooter video game Dead Space.
Isaac Clarke is a systems engineer working for the Concordance Extraction Corporation. Prior to the Second Aegis VII incident, he was part of an emergency response unit of the USG Kellion, sent to the USG Ishimura to investigate and handle the ship’s problems. Apparently the sole survivor of the incident, Isaac became stranded in space for a long period of time before he was rescued by an Earth Government ship. Three years after those events, Isaac was held in an asylum on Titan Station and was diagnosed with mental disorders, the most prominent being dementia that result in haunting illusions that taunt him throughout the game. In Dead Space 3, he still has the blueprint to destroy and create Markers. However, in the Awakening DLC, he witnesses the effects of dementia once again when he is exposed to one of the Brethren Moons.